杨西林，教授，博士生导师
发布时间： 2022-04-22 浏览次数： 13792

杨西林 教授

流行病与卫生统计学系

  

电子邮件: yangxilin@tmu.edu.cn

简历

研究方向:

  1. 妊娠糖尿病流行病学，妊娠糖尿病及危害的评估与防控；

  2. 糖尿病流行病学

学习经历

2000-2002

获博士学位(流行病学),墨尔本大医学院

1998-2000

博士在读(流行病学), 蒙纳什大学医学院(后转学到墨尔本大学)

1988-1991

获工学硕士(营养与食品卫生学),天津轻工业学院

1980-1983

获医学毕业证书(临床医学), 承德医学院

工作经历

2011.11-

教授和系主任, 天津医科大学公共卫生学院流行病与卫生统计学系

2007.3-2011.10

研究助理教授, 香港中文大学医学院医学及治疗学系

2005.3-2007.2

博士后研究员, 香港中文大学医学院内科学及治疗学系

2003.2- 2005.2

副研究员, 香港中文大学公共卫生学院统计学与流行病学中心

2001.11-2002.12

研究分析员,澳大利亚澳洲华人健康促进会

1997.2-1998.1

访问研究员, 澳大利亚蒙纳什大学医学系

1994.6-1997.1

主管技师, 天津市食品卫生监督检验所营养科

1991.6-1994.5

技师,天津市食品卫生监督检验所营养科

1985.5-1988.8

住院医师, 山西省榆次市人民医院儿科和内科

1983.8-1985.4

住院医师,河北新城县医院内科

 

承担的主要课题

2019-

国家自然科学基金面上项目：肠道菌群与胆汁酸的串话在妊娠期糖尿病发病机制中的作用 (项目批准号：81870549)，主持，57.0万人民币,   2019.01.01-2022.12.31。

2018-

国家重大研发计划：“2型糖尿病、糖尿病高风险和妊娠糖尿病危险因素的早期行为干预适宜技术及疗效评价研究”课题三“妊娠糖尿病相关危险因素的控制现况、风险预测模型、干预适宜技术与管理策略研究”(项目编号: 2018YFC1313903),   主持, 215万人民币, 2018.09.01-2021.12.31。

2010-

International Diabetes Federation (IDF) and Lilly’s   Bringing Research In Diabetes to Global Environments and Systems (BRIDGES)– PI:Huiguang   Tian & Xilin Yang; Project title: “A randomized translational study to examine the effects of shared care   versus usual care in management of gestational diabetes in a three-tier   prenatal care network in Tianjin, China” (Ref No. LT09-227), US$393,812,01 Jul 2010 to 31Dec 2013.

近五年发表文章 (主要作者论文)

  1. 杨西林#,*，胡刚*. 天津妊娠期糖尿病预防项目：20年妊娠期糖尿病及并发症防治历程[J]. 中华糖尿病杂志, 2022, 14(1): 12-16.
     doi: 10.3760/cma.j.cn115791-20210202-00067.

  2. Li N#, Li J#, Wang H, Liu J, Li W, Yang K, Huo X, Leng J, Yu Z, Hu G, Fang Z*, Yang X*. Branched-chain amino acids and their interactions with lipid metabolites for increased risk of gestational diabetes. J Clin Endocrinol Metab. 2022 Mar 10;dgac141. doi: 10.1210/clinem/dgac141.

  3. Wang H#, Li J#, Leng J, Li W, Liu J, Yan X, Yu Z, Hu G, Ma RCW, Fang Z*, Wang Y*, Yang X*. The CDKAL1 rs7747752-Bile Acids Interaction Increased Risk of Gestational Diabetes Mellitus: A Nested Case-Control Study. Front Endocrinol (Lausanne). 2022;13:808956. doi: 10.3389/fendo.2022.808956.

  4. Cao S#, Li N#, Zhang C, Liu J, Wang H, Leng J, Wang L, Li W, Yu Z, Hu G, Li J*, Yang X*. Adverse pregnancy outcomes are associated with an increased risk of postpartum prediabetes and diabetes in Chinese women with gestational diabetes. Diabetes Res Clin Pract. 2022;186:109817. doi: 10.1016/j.diabres.2022.109817.

  5. Wang H#, Li N#, Chivese T, Werfalli M, Sun H, Yuen L, Hoegfeldt CA, Elise Powe C, Immanuel J, Karuranga S, Divakar H, Levitt N, Li C, Simmons D, Yang X*. IDF Diabetes Atlas: Estimation of Global and Regional Gestational Diabetes Mellitus Prevalence for 2021 by International Association of Diabetes in Pregnancy Study Group's Criteria. Diabetes Res Clin Pract. 2022;183:109050. doi: 10.1016/j.diabres.2021.109050.

  6. Gao M#, Cao S#, Li N, Liu J, Lyu Y, Li J*, Yang X*. Risks of overweight in the offspring of women with gestational diabetes at different developmental stages: A meta-analysis with more than half a million offspring. Obes Rev. 2022;23(3):e13395. doi: 10.1111/obr.13395.

  7. Liu J, Li J, Li W, Li N, Huo X, Wang H, Leng J, Yu Z, Ma RCW, Hu G, Fang Z*, Yang X*. Predictive values of serum metabolites in early pregnancy and their possible pathways for gestational diabetes: A nested case-control study in Tianjin, China. J Diabetes Complications. 2021;35(12):108048. doi: 10.1016/j.jdiacomp.2021.108048.

  8. Zhou Q#, Wang Y#, Gu Y, Li J, Wang H, Leng J, Li W, Yu Z, Hu G, Ma RCW, Fang ZZ*, Yang X*, Jiang G*. Genetic variants associated with beta-cell function and insulin sensitivity potentially influence bile acid metabolites and gestational diabetes mellitus in a Chinese population. BMJ Open Diabetes Res Care. 2021;9(1):e002287. doi: 10.1136/bmjdrc-2021-002287.

  9. Cui D#, Yang W#, Shao P, Li J, Wang P, Leng J, Wang S, Liu E, Chan JCN, Yu Z, Hu G, Yang X. Interactions between Prepregnancy Overweight and Passive Smoking for Macrosomia and Large for Gestational Age in Chinese Pregnant Women. Obes Facts. 2021;14(5):520-530. doi: 10.1159/000517846

  10. Wang H#, Yang W#, Liu J, Leng J, Li W, Yu Z, Li J, Ma RCW, Hu G, Fang Z, Wang Y*, Yang X*. Serum concentrations of SFAs and CDKAL1 single-nucleotide polymorphism rs7747752 are related to an increased risk of gestational diabetes mellitus. Am J Clin Nutr. 2021;114(5):1698-1707. doi: 10.1093/ajcn/nqab225.

  11. Yang Y#, Li W#, Yang W, Wang L, Liu J, Leng J, Li W, Wang S, Li J, Hu G, Yu Z, Yang X*. Physical activity and sleep duration during pregnancy have interactive effects on caesarean delivery: a population-based cohort study in Tianjin, China. BMC Pregnancy Childbirth. 2021;21(1):406. doi: 10.1186/s12884-021-03788-4.

  12. Li N#, Li J#, Zhang C, Liu G, Leng J, Liu J, Wang L, Li W, Yu Z, Hu G, Chan JCN, Yang X*. Usefulness of cut-off points of International criteria for prediction of post-partum diabetes and prediabetes among Chinese women with gestational diabetes. Diabetes Metab Res Rev. 2021 Nov;37(8):e3456. doi: 10.1002/dmrr.3456.

  13. Li J#, Liu J, Zhang C, Liu G, Leng J, Wang L, Li W, Yu Z, Hu G, Chan JCN, Yang X*. Effects of Lifestyle Intervention of Maternal Gestational Diabetes Mellitus on Offspring Growth Pattern Before Two Years of Age. Diabetes Care. 2021;44(3):e42-e44. doi: 10.2337/dc20-2750.

  14. Li NH#, Yang YZ#, Cui DY#, Li CP, Ma RCW, Li J*, Yang XL*. Effects of lifestyle intervention on long-term risk of diabetes in women with prior gestational diabetes: A systematic review and meta-analysis of randomized controlled trials. Obes Rev. 2021;22(1):e13122. doi: 10.1111/obr.13122.

  15. Liu J#, Li J#, Yang K, Leng J, Li W, Yang W, Huo X, Yu Z, Cw Ma R, Hu G, Fang Z*, Yang X*. Ceramides and their interactive effects with trimethylamine-N-oxide metabolites on risk of gestational diabetes: A nested case-control study. Diabetes Res Clin Pract. 2021;171:108606. doi: 10.1016/j.diabres.2020.108606.

  16. Li N#, Liu J#, Zhang C, Liu G, Leng J, Wang L, Li W, Yu Z, Hu G, Chan JCN, Yang X*. Effects of lifestyle intervention during pregnancy on postpartum diabetes among Chinese women with gestational diabetes. Diabetologia. 2021;64(1):255-258. doi: 10.1007/s00125-020-05308-z.

  17. Li W#, Zhang C#, Leng J, Shao P, Tian H, Zhang F, Dong L, Yu Z, Chan JCN, Hu G, Zhang P*, Yang X*. Within-trial cost-effectiveness of lifestyle intervention using a 3-tier shared care approach for pregnancy outcomes in Chinese women with gestational diabetes. PLoS One. 2020;15(8):e0237738.  doi: 10.1371/journal.pone.0237738.

  18. Li X#, Yang S#, Cao C, Yan X, Zheng L, Zheng L, Da J, Tang X, Ji L, Yang X*, Zhou Z*. Validation of the Swedish diabetes regrouping scheme in adult-onset diabetes in China. J Clin Endocrinol Metab. 2020;105(10):dgaa524. doi: 10.1210/clinem/dgaa524.

  19. Zhao S#, Feng XF#, Huang T#, Luo HH, Chen JX, Zeng J, Gu M, Li J, Sun XY, Sun D, Yang X*, Fang ZZ*, Cao YF*. The association between acylcarnitine metabolites and cardiovascular disease in Chinese patients with type 2 diabetes mellitus. Front Endocrinol (Lausanne). 2020;11:212. doi: 10.3389/fendo.2020.00212.

  20. Liu JN#, Li J#, Li SN, Leng JH, Li WQ, Yang W, Huo XX, Chen LW, Ma RCW,  Hu G, Fang ZZ*, Yang XL*. Circulating Lysophosphatidylcholines in Early Pregnancy and Risk of Gestational Diabetes in Chinese Women. J Clin Endocrinol Metab. 2020;105(4):e982–e993. doi:10.1210/clinem/dgaa058.

  21. Gao S#, Leng J#, Liu H, Wang S, Li W, Wang Y, Hu G, Chan JCN, Yu Z, Zhu H*, Yang X#. Development and validation of an early pregnancy risk score for the prediction of gestational diabetes mellitus in Chinese pregnant women. BMJ Open Diabetes Res Care. 2020;8(1):e000909. doi: 10.1136/bmjdrc-2019-000909.

  22. Li X#, Cao C#, Tang X, Yan X, Zhou H, Liu J, Ji L, Yang X*, Zhou Z*.Prevalence of metabolic syndrome and its determinants in newly-diagnosed adult-onset diabetes in China: A multi-center, cross-sectional survey.Front Endocrinol(Lausanne). 2019;10:661. doi: 10.3389/fendo.2019.00661.

  23. Huo X#, Li J#, Cao YF, Li SN, Shao P, Leng J, Li W, Liu J, Yang K, Ma RCW, Hu G, Fang ZZ*, Yang X*. Trimethylamine-N-oxide metabolites in the early pregnancy and risk of gestational diabetes: a nested case control study. J Clin Endocrinol Metab. 2019;104(11):5529-5539. doi: 10.1210/jc.2019-00710.

  24. Yang W#, Liu J#, Li J, Liu J, Liu H, Wang Y, Leng J, Wang S, Chen H, Chan JCN, Yu Z, Hu G, Yang X*. Interactive effects of prepregnancy overweight and gestational diabetes on macrosomia and large for gestational age: A population-based prospective cohort in Tianjin, China. Diabetes Res Clin Pract. 2019;154:82-89. doi: 10.1016/j.diabres.2019.06.014.

  25. Cao YF#, Li J#, Zhang Z#, Liu J, Sun XY, Feng XF, Luo HH, Yang W, Li SN, Yang X*, Fang ZZ*. Plasma Levels of Amino Acids Related to Urea Cycle and Risk of Type 2 Diabetes Mellitus in Chinese Adults. Front Endocrinol (Lausanne). 2019;10:50. doi: 10.3389/fendo.2019.00050. eCollection 2019.

  26. Ren Y#, Gao L#, Guo X, Huo X, Lu J, Li J, Ji L*, Yang X*.Interactive effect of serum uric acid and total bilirubin for micro-vascular disease of type 2 diabetes in China.J Diabetes Complications. 2018;32(11):1000-1005. doi: 10.1016/j.jdiacomp.2018.09.002.

  27. Liu J, Liu E, Leng J, Pan L, Zhang C, Li W, Li J, Huo X, Chan JCN, Yu Z, Hu G, Yang X*.Indicators of socio-economic status and risk of gestational diabetes mellitus in pregnant women in urban Tianjin, China.Diabetes Res Clin Pract. 2018;144:192-199. doi: 10.1016/j.diabres.2018.08.023.

  28. Li J, Huo X, Cao YF, Li SN, Du Z, Shao P, Leng J, Zhang C, Sun XY, Ma RCW, Fang ZZ*, Yang X*.  Bile acid metabolites in early pregnancy and risk of gestational diabetes in Chinese women: A nested case-control study. EBioMedicine.  2018;35:317-324. doi: 10.1016/j.ebiom.2018.08.015.

  29. Li J#, Leng J#, Li W, Zhang C, Feng L, Wang P, Chan JCN, Hu G, Yu Z, Yang X*. Roles of insulin resistance and beta cell dysfunction in macrosomia among Chinese women with gestational diabetes mellitus. Prim Care Diabetes. 2018; 12(6):565-573.  doi: 10.1016/j.pcd.2018.07.010.

  30. Li J#, Cao YF#, Sun XY, Han L, Li SN, Gu WQ, Song M, Jiang CT, Yang X*, Fang ZZ*. Plasma tyrosine and its interaction with low high-density lipoprotein cholesterol and the risk of type 2 diabetes mellitus in Chinese. J Diabetes Investig. 2019;10(2):491-498. doi: 10.1111/jdi.12898.

  31. Li J#, Wang P#, Zhang C, Leng J, Li N, Wang L, Li W, Liu H, Yu Z, Hu G, Chan JCN, Yang X*. Short body height and pre-pregnancy overweight for increased risk of gestational diabetes mellitus: A population-based cohort study. Front Endocrinol (Lausanne). 2018;9:349. doi: 10.3389/fendo.2018.00349.

  32. Lyu Y#, Luo Y#, Li C, Guo X, Lu J, Wu H, Huo X, Gu W, Yang G, Ji L*, Yang X*.Regional differences in the prevalence of coronary heart disease and stroke in patients with type 2 diabetes in China. J Clin Endocrinol Metab.2018;103(9): 3319-3330doi.org/10.1210/jc.2018-00422

  33. Song C#, Li W#, Leng J, Wang L, Li W, Shi F, Liu G, Zhou J, Yang X*. Passive smoking and postpartum depression among Chinese women: a prospective cohort study in Tianjin, China. Women Health. 2018;20:1-13. doi: 10.1080/03630242.2018.1478365.

  34. Li J#, Song C, Li C, Liu P, Sun Z, Yang X*.Increased risk of cardiovascular disease in women with prior gestational diabetes: A systematic review and meta-analysis.Diabetes Res Clin Pract. 2018;140:324-338. doi: 10.1016/j.diabres.2018.03.054. 

  35. Huo X#, Zhang J#, Guo X, Lu J, Li J, Zhao W, Ji L*, Yang X*.Gender difference in the association of early- vs. late-onset type 2 diabetes with non-fatal microvascular disease in China: A cross-sectional study.Front Endocrinol (Lausanne). 2018;9:15. doi: 10.3389/fendo.2018.00015.

  36. Song C#, Lyu Y#, Li C, Liu P, Li J, Ma RC, Yang X*.Long-term risk of diabetes in women at varying durations after gestational diabetes: a systematic review and meta-analysis with more than 2 million women.Obes Rev. 2018;19(3):421-429. doi: 10.1111/obr.12645. 

  37. Ren Y#, Ren Q#, Lu J, Guo X, Huo X, Ji L*, Yang X*.Low triglyceride as a marker for increased risk of cardiovascular diseases in patients with long-term type 2 diabetes: a cross sectional survey in China.Diabetes Metab Res Rev. 2018;34(2):e2960. doi: 10.1002/dmrr.2960.

  38. Li J#, Luo Y#, Guo X, Huo X, Lu J, Ren Y, Ji L*, Yang X*. Long exposure to type 2 diabetes and risk of non-fatalcoronaryheartdiseaseinChinese femalesand males:findings from a China national cross-sectional study. Diabetes Res Clin Pract. 2018;137:119-127. doi: 10.1016/j.diabres.2017.10.025.

  39. Han Q#, Shao P#, Leng J, Zhang C, Li W, Liu G, Zhang Y, Li Y, Li Z, Ren Y, Chan JC, Yang X*.Interactions between general and central obesity in predicting gestational diabetes mellitus in Chinese pregnant women: A prospective population-based study in Tianjin, China.J Diabetes. 2018;10(1):59-67. doi: 10.1111/1753-0407.12558.

  40. Song C#, Leng J#, Wang L, Li W, Zhang S, Wang W, Liu P, Zhang J, Xie B, Li W, Chan JCN ,Yang X*. ABO blood types and postpartum depression among Chinese women: A prospective cohort study in Tianjin, China.Women Health. 2017:1-14. doi: 10.1080/03630242.2017.1333077.

  41. Leng J#, Wang P, Shao P, Zhang C, Li W, Li N, Wang L, Nan H, Yu Z, Hu G, Chan JC, Yang X*. Passive smoking increased risk of gestational diabetes mellitus independently and synergistically with pre-pregnancy obesity in Tianjin, China. Diabetes Metab Res Rev.2017;33(3):e2861. doi: 10.1002/dmrr.2861.

  42. Wang H#, Leng J, Li WQ, Wang L, Zhang C, Li W, Liu H, Zhang S, Chan J, Hu G, Yu Z, Yang X*. Sleep duration and quality, and risk of gestational diabetes mellitus in pregnant Chinese women. Diabet Med.2017;34(1):44-50. doi: 10.1111/dme.13155.

  43. Song T#,Luo Y#, Wang X, Li J, Han Q, Zhu H, Zhao W,Li W, Sun Z*,Yang X*. Clinical characteristics of Chinese with over 40 years of duration of type 2 diabetes. J Diabetes.  2017;9(1):45-52. doi: 10.1111/1753-0407.12375.

  44. Ren Y#, Jin N#, Hong T, Mu Y, Guo L, Ji Q, Li Q, Yang X*, Ji L*.Interactive effect of serum uric acid and total bilirubin for cardiovascular disease in Chinese patients with type 2 diabetes. Sci Rep. 2016;6:36437. doi: 10.1038/srep36437.

  45. Song C#, Li J, Leng J, Ma RW, Yang X*. Lifestyle intervention can reduce the risk of gestational diabetes: a meta-analysis of randomized controlled trials. Obes Rev.2016;17(10):960-9.doi: 10.1111/obr.12442.

  46. Ren Y#, Ji L#, Mu Y, Hong T*, Ji Q, Guo L, Huang Q, Yang X*. Uric acid, renal function and risk of hypoglycemia in Chinese type 2 diabetes patients. DiabetesMetab Res Rev. 2016;32(8):875-882. doi: 10.1002/dmrr.2809.

  47. Leng J#, Zhang C, Wang P, Li N, Li W, Liu H, Zhang S, Hu G, Yu Z, Ma RC, Chan JC, Yang X*. Plasma levels of alanine aminotransferase in the first trimester identify high risk Chinese women for gestational diabetes.Sci Rep. 2016;6:27291. doi: 10.1038/srep27291.

  48. Leng J#, Liu G, Zhang C, Xin S, Chen F, Li B, Tian H, Yu Z, Tuomilehto J, Hu G, YangX*. Physical activity, sedentary behaviors and risk of gestational diabetes mellitus in Chinese pregnant women. Eur J Endocrinol.2016;174(6):763-73. doi: 10.1530/EJE-15-1103.

  49. Wei F#, Sun N#, Cai C#, Feng S#, Tian J, Shi W, Xu W, Wang Y*,Yang X*, Li WD*.Associations between serum uric acid and the incidence of hypertension: a Chinese senior dynamic cohort study. J Transl Med. 2016;14(1):110. doi: 10.1186/s12967-016-0866-0.

  50. Gu W#, Ren Y#, Ji L, Hong T*, Mu Y, Guo L, Li Q, Tian Q, Yang X*.Non-linear associations of risk factors with hypoglycaemia among Chinese patients with type 2 diabetes. J Diabetes Complications.2016;30(3):462-8. doi: 10.1016/j.jdiacomp.2015.12.024.

  51. Huo X#,Gao L#, Guo L#, Xu W, Wang W, Zhi X, Li L, Ren Y, Qi X, Sun Z,Li W, Ji Q, Ran X, Su B, Hao C, Lu J, Guo X, Zhuo H, Zhang D, Pan C, Weng J,Hu D, Yang X*, Ji L*. Risk of non-fatal cardiovascular diseases in early-onset versus late-onset type 2 diabetes in China: a cross-sectional study. Lancet Diabetes Endocrinol. 2016;4(2):115-24. doi: 10.1016/S2213-8587(15)00508-2.

    社会兼职

    中华预防医学会流行病学分会委员

    天津市心脏学会常委、流行病专业委员会副主委

    天津市临床流行病与循证医学会常委

    天津市预防医学会理事