张强 副教授
劳动卫生与环境卫生学系
电子邮件：qiangzhang@tmu.edu.cn
简历
张强，副教授，硕士生导师，主要研究方向为环境与健康。目前主持在研国家自然科学基金面上项目1项，天津市教委重点项目1项，主持完成包括国家自然科学基金青年项目和天津市自然科学基金面上项目在内的7项课题；发表SCI论文26篇，累计被引用超过1200次（Google Scholar）；参编教材2部。现为天津市“131”创新型人才培养工程第二层次人选；担任中国毒理学会表观遗传毒理专业委员会委员，中国环境诱变剂学会环境应激与健康损害专委会委员，中华预防医学会卫生毒理学分会青年委员会委员等。
研究方向
1. 环境-基因交互作用与人群健康
2. 内分泌干扰物的健康效应研究
学习经历
1. 2002～2007，中国医科大学生物科学与生物技术专业，学士学位
2. 2007～2012，中国医科大学劳动卫生与环境卫生学，博士学位
工作经历
1. 2012～2015，天津医科大学，公共卫生学院劳动卫生与环境卫生学系，讲师
2. 2015～今，天津医科大学，公共卫生学院劳动卫生与环境卫生学系，副教授
3. 2018～2019年，The Johns Hopkins University，Bloomberg School of Public Health，访问学者
主要承担或参与的课题
1. 基于m6A的砷及其甲基化代谢与妊娠期糖尿病的关系及Tef/Per2介导的胎盘胰岛素抵抗机制研究，国家自然科学基金面上项目，82373543，49万元，2024/01-2027/12，在研，主持。
2. 砷和一碳单位代谢营养物交互作用与妊娠期糖尿病关系的巢式病例对照研究，天津市教委，2020ZD14，20万元，2020/12-2024/11，在研，主持。
3. 生命早期砷暴露致雄性生殖损伤的表观遗传学机制研究，天津市自然科学基金，18JCYBJC91900，10万元，2018/10-2021/09，在研，主持。
4. 基因组印记在砷致跨代雄性生殖毒性中的作用机制研究，中国博士后科学基金特别资助，2016T90210，15万元，2016/06-2019/06，在研，主持。
5. 宫内砷暴露对印记基因IGF2/H19的影响及其所致跨代遗传效应的分子机制研究，国家自然科学基金青年项目，81302390，23万元，2014/01-2016/12，已结题，主持。
发表文章（第一/通讯作者）
1. Zhang Q#, Tian M#, Zhang X, Zhang X, Yang X, Lu YY, Li S, Liu L, Li J, Hassanian-Moghaddam H, Tang N, Huang Q*. Metabolic biomarkers linking urinary arsenic species to gestational diabetes mellitus: A cross-sectional study in Chinese pregnant women. Sci Total Environ. 2023 Jun 12; 164761.
2. Yang X#, Zhang Q#, Sun Y, Li C, Zhou H, Jiang C, Li J, Zhang L, Chen X, Tang N*. Joint effect of ambient PM2.5 exposure and vitamin B12 during pregnancy on the risk of gestational diabetes mellitus. Sci Total Environ. 2023 Mar 1; 162514.
3. Liang X#, Guo G#, Wang Y, Wang M, Chen X, Zhang J, Li S, Liu L, Huang Q, Cui B, Zhang M, Sun G, Tang N, Zhang X, Zhang Q*. Arsenic metabolism, N6AMT1 and AS3MT single nucleotide polymorphisms, and their interaction on gestational diabetes mellitus in Chinese pregnant women. Environ Res. 2023 Mar 15; 221:115331.
4. Wang Y#, Wang Y#, Sun Y, Zhang N, Liang X, Luo S, Dai L, Sun C, Yang Y, Li S, Zhang X, Zhang Q*. Serum folate mediates the associations of MTHFR rs1801133 polymorphism with blood glucose levels and gestational diabetes mellitus in Chinese Han pregnant women. Br J Nutr. 2023 Feb 9; 1-9.
5. Li S#, Tian X#, Wang Y, Zhang X, Zhang L, Li C, Li J, Wang C, Liu H, Liu J, Liu H, Yang X, Li W, Leng J, Yang X, Tang N, Zhang Q*. Associations of Maternal rs1801131 Genotype in MTHFR and Serum Folate and Vitamin B12 with Gestational Diabetes Mellitus in Chinese Pregnant Women. Nutrients. 2022. 14(6):1169.
6. Zhang Q#, Zhang X#, Li S, Liu H, Liu L, Huang Q, Hou Y, Liang X, Cui B, Zhang M, Xia L, Zhang L, Li C, Li J, Sun G, Tang N*. Joint effect of urinary arsenic species and serum one-carbon metabolism nutrients on gestational diabetes mellitus: A cross-sectional study of Chinese pregnant women. Environ Int. 2021. 156:106741.
7. Hou Y#, Li S#, Xia L, Yang Q, Zhang L, Zhang X, Liu H, Huo R, Cao G, Huang C, Tian X, Sun L, Cao D, Zhang M, Zhang Q*, Tang N. Associations of urinary phenolic environmental estrogens exposure with blood glucose levels and gestational diabetes mellitus in Chinese pregnant women. Sci Total Environ. 2021. 754:142085.
8. Yin G#, Xia L#, Hou Y, Li Y, Cao D, Liu Y, Chen J, Liu J, Zhang L, Yang Q, Zhang Q*, Tang N. Transgenerational male reproductive effect of prenatal arsenic exposure: abnormal spermatogenesis with Igf2/H19 epigenetic alteration in CD1 mouse. Int J Environ Health Res. 2021. 7:1-13.
9. Zhang Q, Hou Y, Wang D, Xu Y, Wang H, Liu J, Xia L, Li Y, Tang N, Zheng Q, Sun G*. Interactions of arsenic metabolism with arsenic exposure and individual factors on diabetes occurrence: Baseline findings from Arsenic and Non-Communicable disease cohort (AsNCD) in China. Environ Pollut. 2020. 265(Pt A):114968.
10. Li S, Hou Y, Yan X, Wang Y, Shi C, Wu X, Liu H, Zhang L, Zhang X, Liu J, Zhang M, Zhang Q*, Tang N. Joint effects of folate and vitamin B12 imbalance with maternal characteristics on gestational diabetes mellitus. J Diabetes. 2019. 11(9):744-751.
11. Zhang Q#, Yin G#, Liu J, Liang Y, Li Y, Zhao J, Zhang L, Wang B, Tang N*. Association between MTHFR A1298C polymorphism and male infertility: a meta-analysis. J Huazhong Univ Sci Technolog Med Sci. 2017. 37(2):153-160.
12. Zhang Q, Wang D, Zheng Q, Zheng Y, Wang H, Xu Y, Li X, Sun G*. Joint effects of urinary arsenic methylation capacity with potential modifiers on arsenicosis: a cross-sectional study from an endemic arsenism area in Huhhot Basin, northern China. Environ Res. 2014.132: 281-9.
13. Zhang Q, Li Y, Liu J, Wang D, Zheng Q, Sun G*. Differences of urinary arsenic metabolites and methylation capacity between individuals with and without skin lesions in Inner Mongolia, Northern China. Int J Environ Res Public Health. 2014. 11(7):7319-32.
14. Zhang Q, Rodriguez-Lado L, Liu J, Johnson CA, Zheng Q, Sun G*. Coupling predicted model of arsenic in groundwater with endemic arsenism occurrence in Shanxi Province, Northern China. J Hazard Mater. 2013. 262:1147-53.
15. Zhang Q, Rodríguez-Lado L, Johnson CA, Xue H, Shi J, Zheng Q, Sun G*. Predicting the risk of arsenic contaminated groundwater in Shanxi Province, Northern China. Environ Pollut. 2012. 165: 118-23.
16. Zhang Q, Zheng Q, Sun G*. Arsenic-contaminated cold-spring water in mountainous areas of Hui County, Northwest China: A new source of arsenic exposure. Sci Total Environ. 2011. 409(24): 5513-6.
发表文章（其他作者）
1. Cheng M, Liang X, Shi L, Zhang Q, Zhang L, Gong Z, Luo S, Wang X, Zhang X*. Folic acid deficiency exacerbates the inflammatory response of astrocytes after ischemia-reperfusion by enhancing the interaction between IL-6 and JAK-1/pSTAT3. CNS Neurosci Ther. 2023 Feb 16.
2. Liang X, Shi L, Wang M, Zhang L, Gong Z, Luo S, Wang X, Zhang Q, Zhang X*. Folic acid ameliorates synaptic impairment following cerebral ischemia/reperfusion injury via inhibiting excessive activation of NMDA receptors. J Nutr Biochem. 2023 Feb;112:109209.
3. Wang M, Liang X, Zhang Q, Luo S, Liu H, Wang X, Sai N, Zhang X*. Homocysteine can aggravate depressive like behaviors in a middle cerebral artery occlusion/reperfusion rat model: a possible role for NMDARs-mediated synaptic alterations. Nutr Neurosci. 2022 Apr 13:1-13.
4. Yang L, Ye Q, Zhang X, Li K, Liang X, Wang M, Shi L, Luo S, Zhang Q, Zhang X*. Pyrroloquinoline quinone extends Caenorhabditis elegans' longevity through the insulin/IGF1 signaling pathway-mediated activation of autophagy. Food Funct. 2021 Nov 15;12(22):11319-11330.
5. Dong Z, Liang X, Zhang Q, Luo S, Liu H, Wang X, Sai N, Zhang X*. Folic Acid Deficiency Enhances the Tyr705 and Ser727 Phosphorylation of Mitochondrial STAT3 in In Vivo and In Vitro Models of Ischemic Stroke. Transl Stroke Res. 2021 Oct;12(5):829-843.
6. Gou Y, Ye Q, Liang X, Zhang Q, Luo S, Liu H, Wang X, Sai N, Zhang X*. Homocysteine restrains hippocampal neurogenesis in focal ischemic rat brain by inhibiting DNA methylation. Neurochem Int. 2021 Jul;147:105065.
7. Freeman DM, O'Neal R, Zhang Q, Bouwer EJ, Wang Z*. Manganese-induced Parkinsonism in mice is reduced using a novel contaminated water sediment exposure model. Environ Toxicol Pharmacol. 2020. 78:103399.
8. Zhu Y#, Li Y#, Lou D, Gao Y, Yu J, Kong D, Zhang Q, Jia Y*, Zhang H*, Wang Z*. Sodium arsenite exposure inhibits histone acetyltransferase p300 for attenuating H3K27ac at enhancers in mouse embryonic fibroblast cells. Toxicol Appl Pharmacol. 2018. 357:70-79.
9. Rodríguez-Lado L, Sun G, Berg M, Zhang Q, Xue H, Zheng Q, Johnson CA*. Groundwater arsenic contamination throughout China. Science. 2013. 341(6148): 866-8.
10. Xi S, Zheng Q, Zhang Q, Sun G*. Metabolic profile and assessment ofoccupational arsenic exposure in copper- and steel-smelting workers in China. Int Arch Occup Environ Health. 2011. 84: 347-353.
参编教材
1. 职业病三级预防理论与实践. 人民卫生出版社. 2022年6月30日. ISBN：9787117332163.
2. 突发公共卫生事件应对与处置. 北京大学医学出版社. 2016年7月. ISBN：9787565914034.
研究生培养情况
硕士生毕业4名，在读6名
招生专业
劳动卫生与环境卫生学；公共卫生与预防医学
社会兼职
1. 中国毒理学会表观遗传毒理专业委员会委员
2. 中国环境诱变剂学会环境应激与健康损害专委会委员
3. 中华预防医学会卫生毒理学分会青年委员会
4. 中国环境诱变剂学会致突变专委会青年委员
5. 天津市预防医学会劳动卫生与职业病分会委员
6. 天津市预防医学会环境卫生分会委员
7. 天津市预防医学会毒理学分会委员
8. 《解放军预防医学杂志》编委
获奖情况
1. 第五期天津医科大学卓越教师，2022年6月
2. 多次指导本科生在国家级大学生创新创业训练计划项目（2021年，国家级立项）和全国大学生基础医学创新研究暨实验设计论坛（2023年，铜奖）以及“挑战杯”天津市大学生课外学术科技作品竞赛（2015年，三等奖）中立项和获奖。