徐 卫 历，教授，博士生导师
发布时间： 2022-04-22 浏览次数： 9466

  

  徐 卫 历 教授

流行病与卫生统计学系

  

电子邮件 xuweili@tmu.edu.cn /weilixu@hotmail.com

 

简历

徐 卫 历，博士，天津医科大学公共卫生学院流行病与卫生统计学系教授，博士研究生导师，天津市心脏学会流行病分会副主任委员。主要研究方向是老年病流行病学及营养流行病学。近几年来获得国家自然科学基金。在J Am Coll Cardiol，Alzheimer Dementia，Diabetes Care，JAMA Neurol，Neurology，Diabetologia，Int J Cancer以及Nuerobiol Aging，Gerontology，Clinical Nutrition，Nueroigmaing等国际学术期刊上发表SCI论文120余篇，论文总引用次数5094余次，H-Index=35。

 

研究方向

近年来的主要研究方向是：老年病流行病学。

 

 

学习经历

1. 2005～2008年，瑞典卡洛林斯卡研究院，博士学位。

2. 1987～1990年，天津医科大学卫生系，硕士学位。

3. 1982～1987年，天津医科大学卫生系，学士学位。

 

主要承担或参与的课题

  1. 茶多酚对改善认知功能和预防老年痴呆的作用及其抗氧化机制的研究，国家自然科学基金面上项目，81771519，59万元，2018/01-2021/12。

  2. 糖尿病患者中对抗老年痴呆的代偿机制的研究，瑞典科学研究理事会医学研究领域项目，2017-00981，480万瑞典克朗（≈48万欧元），2018/01-2021/12。

  3. 认知储存对认知功能的影响，天津医科大学人才项目，30万元，2016/01-2019/12。

  4. “3型糖尿病”在2型糖尿病患者中的发生与发展，卡洛林斯卡研究院面向全球的年轻学者资助项目，300万瑞典克朗（≈31,5万欧元），20130022，2013/01-2015/12。

  5. 肥胖者怎样战胜老年痴呆?瑞典科学研究理事会，2012-0022, 243万瑞典克朗（≈25.58万欧元），2013/01-2015/12。

  6. 新的饮食策略改善欧洲老年人认知功能的作用与抗炎机制的研究，FP7-KBBE-2010-4，8万欧元，2010/01-2015/10。

     

    近五年发表文章（#第一作者；*通讯作者）

  7. Lulu Zhang, Wenzhe Yang, Xuerui Li, Abigail Dove, Xiuying Qi, Kuan-Yu Pan, Weili Xu*. Association of life-course traumatic brain injury with dementia risk: a nationwide twin study.Alzheimers Dement. 2022 Mar 28. doi: 10.1002/alz.12671.

  8. Xuerui Li#, Wenzhe Yang#, Jiao Wang, Abigail Dove, Xiuying Qi, David A Bennett, Weili Xu*. High lifelong cognitive reserve prolongs disability-free survival: the role of cognitive function. Alzheimers Dement. 2022 Mar 28. doi: 10.1002/alz.12670.

  9. Jiao Wang, Abigail Dove, Ruixue Song, Xiuying Qi, Jun Ma, David A Bennett, Xu Weili*. Poor pulmonary function is associated with mild cognitive impairment, its progression to dementia, and brain pathologies: a community-based cohort study. Alzheimers Dement. 2022 Feb 20. doi: 10.1002/alz.12625.

4.     Jingya Wang#, Yang Bai#, Zihang Zeng, Jun Wang, Ping Wang, Yongai Zhao, Weili Xu, Yun Zhu*, Xiuying Qi*. Association between life-course cigarette smoking and metabolic syndrome: a discovery-replication strategy.Diabetol Metab Syndr. 2022 Jan 15;14(1):11.doi: 10.1186/s13098-022-00784-2.

  1. Ruixue Song, Kuan-Yu Pan, Hui Xu, Xiuying Qi, Aron S Buchman, David A Bennett, Weili Xu*. Association of cardiovascular risk burden with risk of dementia and brain pathologies: a population-based cohort study. Alzheimers Dement. 2021 Dec; 17(12):1914-1922. doi: 10.1002/alz.12343.

  2. Wenzhe Yang#, Kaiwang Cui#, Xuerui Li, Jing Zhao, Zihang Zeng, Ruixue Song, Xiuying Qi*, Weili Xu*. Effect of polyphenols on cognitive function: evidence from population-based studies and clinical trials. J Nutr Health Aging. 2021;25(10):1190-1204. doi: 10.1007/s12603-021-1685-4.

  3. Jie Guo*, Xuerui Li, Rongrong Yang, Anna Marseglia, Abigail Dove, Kristina Johnell, Weili Xu. Association of body mass index and its long-term changes with cardiometabolic diseases: a nationwide twin study. Clin Nutr. 2021 Nov;40(11):5467-5474. doi: 10.1016/j.clnu.2021.09.030.

  4. Abigail Dove*#, Ying Shang#, Weili Xu, Giulia Grande, Erika J Laukka, Laura Fratiglioni, Anna Marseglia. The impact of diabetes on cognitive impairment and its progression to dementia. Alzheimers Dement. 2021 Nov;17(11):1769-1778. doi: 10.1002/alz.12482.

  5. Xuerui Li, Ruixue Song, Xiuying Qi*, Hui Xu, Wenzhe Yang, Miia Kivipelto, David A Bennett, Weili Xu*. Influence of cognitive reserve on cognitive trajectories: role of brain pathologies. Neurology. 2021 Oct 26;97(17):e1695-e1706. doi: 10.1212/WNL.0000000000012728.

  6. Jiao Wang#, Ruixue Song#, Abigail Dove, Xiuying Qi, Jun Ma, Erika J Laukka, David A Bennett, Xu Weili*. Pulmonary function is associated with cognitive decline and structural brain differences. Alzheimers Dement. 2021 Sep 30. doi: 10.1002/alz.12479.

  7. Wenzhe Yang#, Xuerui Li#, Kuan-Yu Pan, Rongrong Yang, Ruixue Song, Xiuying Qi, Nancy L Pedersen, Weili Xu*. Association of life-course depression with the risk of dementia in late life: a nationwide twin study. Alzheimers Dement. 2021 Aug;17(8):1383-1390. doi: 10.1002/alz.12303.

  8. Zhuoyu Sun#, Shuqi Wang#, Rongrong Yang, Xuerui Li, Yumeng Yang, Xiuying Qi, Yaomei Ma*, Weili Xu*. Gestational diabetes mellitus and risks of gynecologic cancers: results from a nationwide Swedish twin study. Gynecol Oncol. 2021 Jul;162(1):142-147. doi: 10.1016/j.ygyno.2021.03.028.

  9. Christina S Dintica*, Miriam L Haaksma, Jonas K Olofsson, David A Bennett, Weili Xu*. Joint trajectories of episodic memory and odor identification in older adults: patterns and predictors. Aging (Albany NY). 2021 Jul 7;13(13):17080-17096. doi: 10.18632/aging.203280.

  10. Xuerui Li, Rongrong Yang, Wenzhe Yang, Hui Xu, Ruixue Song, Xiuying Qi*, Weili Xu*. Association of low birth weight with cardiometabolic diseases in Swedish twins: a population-based cohort study. BMJ Open. 2021 Jun 28;11(6):e048030. doi: 10.1136/bmjopen-2020-048030.

  11. Ying Shang*, Laura Fratiglioni, Davide Liborio Vetrano, Abigail Dove, Anna-Karin Welmer, Weili Xu*. Not only diabetes but also prediabetes leads to functional decline and disability in older adults. Diabetes Care. 2021 Mar;44(3):690-698. doi: 10.2337/dc20-2232.

  12. Rongrong Yang#, Hui Xu#, Nancy L Pedersen, Xuerui Li, Jing Yu, Cuiping Bao, Xiuying Qi*, Weili Xu*. A healthy lifestyle mitigates the risk of heart disease related to type 2 diabetes: a prospective nested case-control study in a nationwide Swedish twin cohort. Diabetologia. 2021 Mar;64(3):530-539. doi: 10.1007/s00125-020-05324-z.

  13. Rui Wang*, Chengxuan Qiu, Christina S Dintica, Ying Shang, Amaia Calderón Larrañaga, Hui-Xin Wang, Weili Xu*. Shared risk and protective factors between Alzheimer's disease and ischemic stroke: a population-based longitudinal study. Alzheimers Dement. 2021 Feb;17(2):191-204. doi: 10.1002/alz.12203.

  14. Anna Marseglia*, Alexander Darin-Mattsson, Grégoria Kalpouzos, Giulia Grande, Laura Fratiglioni, Serhiy Dekhtyar, Weili Xu*.Can active life mitigate the impact of diabetes on dementia and brain aging?. Alzheimers Dement. 2020 Nov;16(11):1534-1543. doi: 10.1002/alz.12142.

  15. Zhi Cao, Christina Dintica, Ying Shang, Yangyang Cheng, Shu Li, Hongxi Yang, Li Sun, Weili Xu, Yaogang Wang*. The role of cognitive impairment, physical disability, and chronic conditions in the association of sleep duration with all-cause mortality among very old adults.J Am Med Dir Assoc. 2020 Oct;21(10):1458-1463.e2. doi: 10.1016/j.jamda.2020.02.017.

  16. Kaiwang Cui#, Ruixue Song#, Hui Xu, Ying Shang, Xiuying Qi*, Aron S Buchman, David A Bennett, Weili Xu*. Association of cardiovascular risk burden with risk and progression of disability: mediating role of cardiovascular disease and cognitive decline. J Am Heart Assoc. 2020 Sep 15;9(18):e017346. doi: 10.1161/JAHA.120.017346.

  17. Ying Shang*, Laura Fratiglioni, Anna Marseglia, Anna Plym, Anna-Karin Welmer, Hui-Xin Wang, Rui Wang, Weili Xu*. Association of diabetes with stroke and post-stroke dementia: a population-based cohort study. Alzheimers Dement. 2020 Jul;16(7):1003-1012. doi: 10.1002/alz.12101.

  18. Hui Xu, Rongrong Yang, Christina Dintica, Xiuying Qi*, Ruixue Song, David A Bennett, Weili Xu*. Association of lifespan cognitive reserve indicator with the risk of mild cognitive impairment and its progression to dementia. Alzheimers Dement. 2020 Jun;16(6):873-882. doi: 10.1002/alz.12085.

  19. Ruixue Song, Hui Xu, Christina S Dintica, Kuan-Yu Pan, Xiuying Qi*, Aron S Buchman,David A Bennett, Weili Xu*. Associations between cardiovascular risk, structural brain changes, and cognitive decline. J Am Coll Cardiol. 2020 May 26;75(20):2525-2534. doi: 10.1016/j.jacc.2020.03.053.

  20. Christina S Dintica*, Anna Marseglia, Inger Wårdh, Elgestad Per Stjernfeldt, Debora Rizzuto, Ying Shang, Weili Xu*, Nancy L Pedersen. The relation of poor mastication with cognition and dementia risk: a population-based longitudinal study. Aging (Albany NY). 2020 Apr 30;12(9):8536-8548. doi: 10.18632/aging.103156.

  21. Zhida Wang, Anna Marseglia, Ying Shang, Christina Dintica, Cesare Patrone, Weili Xu*. Leisure activity and social integration mitigate the risk of dementia related to cardiometabolic diseases: a population-based longitudinal study. Alzheimers Dement. 2020 Feb;16(2):316-325. doi: 10.1016/j.jalz.2019.09.003.

  22. Hui Xu#, Zhida Wang#, Xuerui Li, Meijuan Fan, Cuiping Bao, Rongrong Yang, Fei Song, Weili Xu *, Xiuying Qi*. Osteoporosis and osteopenia among patients with type 2 diabetes aged ≥50: role of sex and clinical characteristics.J Clin Densitom. Jan-Mar 2020;23(1):29-36. doi: 10.1016/j.jocd.2019.04.004.

  23. Federica Prinelli*, Laura Fratiglioni, Massimo Musicco, Ingegerd Johansson, Fulvio Adorni, Behnaz Shakersain, Debora Rizzuto, Weili Xu*. The impact of nutrient-based dietary patterns on cognitive decline in older adults.Clin Nutr. 2019 Dec;38(6):2813-2820. doi: 10.1016/j.clnu.2018.12.012.

  24. Hui Xu#, Rongrong Yang#, Xiuying Qi*, Christina Dintica, Ruixue Song, David A Bennett, Weili Xu*. Association of lifespan cognitive reserve indicator with dementia risk in the presence of brain pathologies. JAMA Neurol. 2019 Oct 1;76(10):1184-1191. doi: 10.1001/jamaneurol.2019.2455.

  25. Federica Prinelli*, Laura Fratiglioni, Grégoria Kalpouzos, Massimo Musicco, Fulvio Adorni, Ingegerd Johansson, Anna Marseglia, Weili Xu*. Specific nutrient patterns are associated with higher structural brain integrity in dementia-free older adults.Neuroimage. 2019 Oct 1;199:281-288. doi: 10.1016/j.neuroimage.2019.05.066.

  26. Zhi Cao#, Rui Wang#, Yangyang Cheng, Hongxi Yang, Shu Li, Li Sun, Weili Xu, Yaogang Wang*. Adherence to a healthy lifestyle counteracts the negative effects of risk factors on all-cause mortality in the oldest-old. Aging (Albany NY). 2019 Sep 16;11(18):7605-7619. doi: 10.18632/aging.102274.

  27. Fei Ma#, Xin Lv#, Yue Du, Hui Chen, Shuai Liu, Jiangang Zhao, Yiming Gao, Peilin An, Xuan Zhou, Aili Song, Changqing Sun, Guangshun Wang, Yong Ji, Xinyan Wang, Weili Xu, Guowei Huang*. Association of leukocyte telomere length with mild cognitive impairment and Alzheimer's disease: role of folate and homocysteine. Dement Geriatr Cogn Disord. 2019;48(1-2):56-67. doi: 10.1159/000501958.

  28. Fei Ma#, Xuan Zhou#, Qing Li, Jiangang Zhao, Aili Song, Peilin An, Yue Du, Weili Xu, Guowei Huang*. Effects of folic acid and Vitamin B12, alone and in combination on cognitive function and inflammatory factors in the elderly with mild cognitive impairment: a single-blind experimental design. Curr Alzheimer Res. 2019;16(7):622-632. doi: 10.2174/1567205016666190725144629.

  29. Rongrong Yang, Nancy L Pedersen, Cuiping Bao, Weige Xu, Hui Xu, Ruixue Song, Xiuying Qi*, Weili Xu*. Type 2 diabetes in midlife and risk of cerebrovascular disease in late life: a prospective nested case-control study in a nationwide Swedish twin cohort. Diabetologia. 2019 Aug;62(8):1403-1411. doi: 10.1007/s00125-019-4892-3.

  30. Cuiping Bao#, Rongrong Yang#, Nancy L Pedersen, Weige Xu, Hui Xu, Ruixue Song,Xiuying Qi*, Weili Xu*. Overweight in midlife and risk of cancer in late life: a nationwide Swedish twin study. Int J Cancer. 2019 May 1;144(9):2128-2134. doi: 10.1002/ijc.32005.

  31. Christina S Dintica*, Anna Marseglia, Debora Rizzuto, Rui Wang, Janina Seubert, Konstantinos Arfanakis, David A Bennett, Weili Xu*. Impaired olfaction is associated with cognitive decline and neurodegeneration in the brain. Neurology. 2019 Feb 12;92(7):e700-e709. doi: 10.1212/WNL.0000000000006919.

  32. Anna Marseglia*, Hui-Xin Wang, Debora Rizzuto, Laura Fratiglioni, Weili Xu*. Participating in mental, social, and physical leisure activities and having a rich social network reduce the incidence of diabetes-related dementia in a cohort of Swedish older adults. Diabetes Care. 2019 Feb;42(2):232-239. doi: 10.2337/dc18-1428.

  33. Fei Ma, Qing Li, Xuan Zhou, Jiangang Zhao, Aili Song, Wen Li, Huan Liu, Weili Xu, Guowei Huang*. Effects of folic acid supplementation on cognitive function and Aβ-related biomarkers in mild cognitive impairment: a randomized controlled trial. Eur J Nutr. 2019 Feb;58(1):345-356. doi: 10.1007/s00394-017-1598-5.

  34. Anna Marseglia*, Laura Fratiglioni, Grégoria Kalpouzos, Rui Wang, Lars Bäckman, Weili Xu*. Prediabetes and diabetes accelerate cognitive decline and predict microvascular lesions: a population-based cohort study. Alzheimers Dement. 2019 Jan;15(1):25-33. doi: 10.1016/j.jalz.2018.06.3060.

  35. Behnaz Shakersain, Debora Rizzuto, Hui-Xin Wang, Gerd Faxén-Irving, Federica Prinelli, Laura Fratiglioni, Weili Xu*. An active lifestyle reinforces the effect of a healthy diet on cognitive function: a population-based longitudinal study. Nutrients. 2018 Sep 13;10(9):1297. doi: 10.3390/nu10091297.

  36. Cuiping Bao, Nancy L Pedersen, Rongrong Yang, Anna Marseglia, Weige Xu, Yaogang Wang, Xiuying Qi*, Weili Xu*. Diabetes in midlife and risk of cancer in late life: a nationwide Swedish twin study. Int J Cancer. 2018 Aug 15;143(4):793-800. doi: 10.1002/ijc.31365.

  37. Christina S Dintica, Debora Rizzuto, Anna Marseglia, Grégoria Kalpouzos, Anna-Karin Welmer, Inger Wårdh, Lars Bäckman, Weili Xu*. Tooth loss is associated with accelerated cognitive decline and volumetric brain differences: a population-based study. Neurobiol Aging. 2018 Jul;67:23-30. doi: 10.1016/j.neurobiolaging.2018.03.003.

  38. Anna Marseglia*, Weili Xu*, Laura Fratiglioni, Cristina Fabbri, Agnes A M Berendsen, Agata Bialecka-Debek, Amy Jennings, Rachel Gillings, Nathalie Meunier, Elodie Caumon, Susan Fairweather-Tait, Barbara Pietruszka, Lisette C P G M De Groot, Aurelia Santoro, Claudio Franceschi. Effect of the NU-AGE diet on cognitive functioning in older adults: a randomized controlled trial. Front Physiol. 2018 Apr 4;9:349. doi: 10.3389/fphys.2018.00349.

  39. Anna Marseglia*, Anna K Dahl Aslan, Laura Fratiglioni, Giola Santoni, Nancy L Pedersen, Weili Xu. Cognitive trajectories of older adults with prediabetes and diabetes: a population-based cohort study. J Gerontol A Biol Sci Med Sci. 2018 Mar 2;73(3):400-406. doi: 10.1093/gerona/glx112.

  40. Behnaz Shakersain, Debora Rizzuto, Susanna C Larsson, Gerd Faxén-Irving, Laura Fratiglioni, Weili Xu*. The nordic prudent diet reduces risk of cognitive decline in the Swedish older adults: a population-based cohort study. Nutrients. 2018 Feb 17;10(2):229. doi: 10.3390/nu10020229.

  41. Stina Ek*, Debora Rizzuto, Laura Fratiglioni, Kristina Johnell, Weili Xu, Anna-Karin Welmer. Risk profiles for injurious falls in people over 60: a population-based cohort study. J Gerontol A Biol Sci Med Sci. 2018 Jan 16;73(2):233-239. doi: 10.1093/gerona/glx115.

46.Hua Zhang#, Xu Hui#, Fei Song, Weili Xu, Stephanie Paillard-Borg, Xiuying Qi*. Relation of socioeconomic status to overweight and obesity: a large population-based study of Chinese adults. Ann Hum Biol. 2017Sep; 44(6):495-501.doi: 10.1080/03014460.2017.1328072.

47.Anna-Karin Welmer*, Debora Rizzuto, Marti G Parker, Weili Xu. Impact of tooth loss on walking speed decline over time in older adults: a population-based cohort study. Aging Clin Exp Res. 2017 Aug;29(4):793-800. doi: 10.1007/s40520-016-0630-6.

48.Hua Zhang#, Meiyu Deng#, Hui Xu, Huili Wang, Fei Song, Cuiping Bao, Stéphanie Paillard-Borg, Weili Xu, Xiuying Qi*. Pre- and undiagnosed-hypertension in urban Chinese adults: a population-based cross-sectional study. J Hum Hypertens. 2017 Apr;31(4):263-269. doi: 10.1038/jhh.2016.73.

49.Fei Song#, Cuiping Bao#, Meiyu Deng, Hui Xu, Meijuan Fan, Stéphanie Paillard-Borg, Weili Xu, Xiuying Qi*. The prevalence and determinants of hypothyroidism in hospitalized patients with type 2 diabetes mellitus. Endocrine. 2017Jan;55(1):179-185. doi: 10.1007/s12020-016-1095-2.

50.汪煜，杨蓉蓉，包翠萍，徐会，宋瑞雪，齐秀英，PEDERSEN Nancy L，徐 卫 历*. 瑞典双生子人群2型糖尿病与非黑色素瘤皮肤癌关系的研究. 中国慢性病预防与控制. 2019, 27(5):336-339.

 

研究生培养情况

博士生毕业2名，在读4名。

硕士生毕业2名，在读2名。

 

招生专业

流行病与卫生统计学

 

社会兼职

1. 天津市心脏学会流行病分会副主任委员

2. 天津市预防医学会流行病学分会会员

 

获奖情况

1. 2008年获得瑞典糖尿病协会办法的“最佳临床糖尿病论文答辩”奖。

2. 策略性研究规划-流行病学青年学者奖, 2010-2011。