天津医科大学陈曦，教授，博士生导师

陈曦教授

劳动卫生与环境卫生学系

电子邮件

chenxi@tmu.edu.cn

电话：186********3027

简历

陈曦，教授，主要研究方向为环境与健康，主持在研国家自然基金面上项目，主持完成国家自然基金青年基金、天津市科委应用基础与前沿项目、中国博士后基金等项目，荣获天津市高校中青年骨干创新人才培养计划人选，天津市“131”创新型人才培养工程第二层次人选，任中华预防医学会环境卫生分会委员，中华预防医学会卫生毒理分会委员，中国毒理学会工业毒理学专业委员会委员，中国环境诱变剂学会生物标志物专业委员会委员等学术委员。

研究方向：环境内分泌干扰物和持久性有机污染物的健康影响。

学习经历

2009-2012年，天津医科大学，流行病学与卫生统计学，博士学位

2006-2009年，天津医科大学，劳动卫生与环境卫生学，硕士学位

2001-2006年，天津医科大学，预防医学专业，学士学位

工作经历

2021.01至今，天津医科大学，公共卫生学院，教授

2015.01-2020.12，天津医科大学，公共卫生学院，副教授

2015.06-2016.07，美国加州大学伯克利分校，访问学者

2012.07-2014.12，天津医科大学，公共卫生学院，讲师

主要承担或参与的课题

1. 全氟化合物暴露对乳腺癌发生的影响及雌激素受体介导机制研究. 国家自然科学基金面上项目. 81973002. 主持. 在研. 56万. 2020.01.01-2023.12.31

2. 二噁英通过干扰线粒体相关蛋白影响人胎盘类固醇激素生成的机制初探，国家自然科学基金青年项目，81402653，2015.1-2017.12，已结题，主持。

3. 神经元与胶质细胞反馈调节在TCDD诱导神经毒性中的作用，天津市科委应用基础与前沿项目，14JCQNJC11300，2014.4-2017.3，已结题，主持。

4. 四溴双酚A影响人胎盘激素生成的线粒体干扰机制研究，中国博士后科学基金第61批面上项目一等资助，2017M610122，2017.5-2019.9，在研，主持。

5 EZH2介导二噁英影响ER阳性乳腺癌发生发展的表观遗传机制研究，国家自然科学基金面上项目，81573115，2016/01-2019/12，在研，参加

6. 大气污染对呼吸和心血管系统健康影响的早期识别技术，“十三五”国家重点研发计划“大气污染成因与控制技术研究”重点专项，2017YFC0211600；课题5：大气污染对呼吸和心血管系统影响的早期效应标志物人群验证，2017YFC0211605，在研，参加

近五年发表文章

1. Li X, Song F, Liu X, Shan A, Huang Y, Yang Z, Li H, Yang Q, Yu Y, Zheng H, Cao XC, Chen D, Chen KX, Chen X*, Tang NJ*. Perfluoroalkyl substances (PFASs) as risk factors for breast cancer: a case-control study in Chinese population. Environ Health. 2022 Sep 9;21(1):83.

2. Zhang A, Wang R, Liu Q, Yang Z, Lin X, Pang J, Li X, Wang D, He J, Li J, Zhang M, Yu Y, Cao XC, Chen X, Tang NJ. Breast adipose metabolites mediates the association of tetrabromobisphenol a with breast cancer: A case-control study in Chinese population. Environ Pollut. 2023 Jan 1;316(Pt 1):120701.

3. Li X, Sun X, Zhang A, Pang J, Li Y, Yan M, Xu Z, Yu Y, Yang Z, Chen X, Wang X, Cao XC, Tang NJ. Breast microbiome associations with breast tumor characteristics and neoadjuvant chemotherapy: A case-control study. Front Oncol. 2022 Sep 12;12:926920.

4. Anqi Shan#, Xi Chen#, Xueli Yang, Baoqun Yao, Fengchao Liang, Ze Yang, Fangchao Liu, Song Chen, Xiaochang Yan, Jianfeng Huang, Shaoye Bo, Nai-Jun Tang, Dongfeng Gu, Hua Yan*. Association between long-term exposure to fine particulate matter and diabetic retinopathy among diabetic patients: A national cross-sectional study in China. Environ Int. 2021 Apr 17;154:106568.

5. Wang L, Guo P, Tong H, Wang A, Chang Y, Guo X, Gong J, Song C, Wu L, Wang T, Hopke PK, Chen X*, Tang NJ*, Mao H*. Traffic-related metrics and adverse birth outcomes: A systematic review and meta-analysis. Environ Res. 2020 Sep;188:109752.

6. Anqi Shan, Ling Leng, Jing Li, Xiu-mei Luo, Ya-jiao Fan, Qiaoyun Yang, Qun-hui Xie, Yang-sheng Chen, Chun-sheng Ni, Li-ming Guo, Hua Tang, Xi Chen*, Nai-jun Tang*. TCDD-induced antagonism of MEHP-mediated migration and invasion partly involves aryl hydrocarbon receptor in MCF7 breast cancer cells. Journal of Hazardous Materials. Volume 398, 5 November 2020, 122869. doi.org/10.1016/j.jhazmat.2020.122869

7. Shan A, Zhang Y, Zhang LW, Chen X, Li X, Wu H, Yan M, Li Y, Xian P, Ma Z, Li C, Guo P, Dong GH, Liu YM, Chen J, Wang T, Zhao BX, Tang NJ*. Associations between the incidence and mortality rates of type 2 diabetes mellitus and long-term exposure to ambient air pollution: A 12-year cohort study in northern China. Environ Res. 2020 Jul;186:109551.

8. Yan M, Li C, Zhang L, Chen X, Yang X, Shan A, Li X, Wu H, Ma Z, Zhang Y, Guo P, Dong G, Liu Y, Chen J, Wang T, Zhao B, Tang NJ*. Association between long-term exposure to Sulfur dioxide pollution and hypertension incidence in northern China: a 12-year cohort study. Environ Sci Pollut Res Int. 2020 Jun; 27(17): 21826-21835.

9. Shan A#, Zhang Y, Zhang LW, Chen X, Li X, Wu H, Yan M, Li Y, Xian P, Ma Z, Li C, Guo P, Dong GH, Liu YM, Chen J, Wang T, Zhao BX, Tang NJ*. Associations between the incidence and mortality rates of type 2 diabetes mellitus and long-term exposure to ambient air pollution: A 12-year cohort study in northern China. Environ Res, 2020 Jul; 186: 109551.

10. Wang L#, Guo P, Tong H, Wang A, Chang Y, Guo X, Gong J, Song C, Wu L, Wang T, Hopke PK, Chen X*, Tang NJ*, Mao H*. Traffic-related metrics and adverse birth outcomes: A systematic review and meta-analysis. Environ Res, 2020 May 30; 188: 109752.

11. Shan A, Li M, Li X, Li Y, Yan M, Xian P, Chang Y, Chen X*, Tang NJ. BDE-47 decreases progesterone levels in BeWo cells by interfering with mitochondrial functions and genes related to cholesterol transport. Chem Res Toxicol. 2019 Feb 4. doi: 10.1021/acs.chemrestox.8b00312. [Epub ahead of print]

12. Zhang HJ, Liu YN, Xian P, Ma J, Sun YW, Chen JS, Chen X*, Tang NJ*. Maternal exposure to TCDD during gestation advanced sensory-motor development, but induced impairments of spatial learning and memory in adult male rat offspring. Chemosphere. 2018 Aug 23;212:678-686.

13. Chen X, Wang X, Huang JJ, Zhang LW, Song FJ, Mao HJ, Chen KX, Chen J, Liu YM, Jiang GH, Dong GH, Bai ZP, Tang NJ*. Nonmalignant respiratory mortality and long-term exposure to PM10 and SO2: A 12-year cohort study in northern China. Environ Pollut. 2017 Aug 30;231(Pt 1):761-767.

14. Chen X, Zhang LW, Huang JJ, Song FJ, Zhang LP, Qian ZM, Trevathan E, Mao HJ, Han B, Vaughn M, Chen KX, Liu YM, Chen J, Zhao BX, Jiang GH, Gu Q, Bai ZP, Dong GH, Tang NJ*. Long-term exposure to urban air pollution and lung cancer mortality: A 12-year cohort study in Northern China. Sci Total Environ. 2016 Nov 15;571:855-61.

15. Chen X, Chen JS, Zhang L, Li JG, Yao L, Self SG, Sun X, Tang NJ*. Levels of PCDDs, PCDFs and dl-PCBs in the blood of childbearing-aged women living in the vicinity of a chemical plant in Tianjin: A primary study. Chemosphere. 2015, 118: 1-4.

16. Chen X, Leng L, Yu H, Yang XL, Dong GH, Yue S, Chen JS, Tang NJ*. Psychological distress and dyslipidemia in chinese police officers: a 4-year follow-up study in Tianjin, China. J Occup Environ Med. 2015, 57(4):400-5.

17. Chen X, Zhou QH, Leng L, Chen X, Sun ZR, Tang NJ*. Effects of di(n-butyl) and monobutyl phthalate on steroidogenesis pathways in the murine Leydig tumor cell line MLTC-1. Environ Toxicol Pharmacol. 2013, 36(2):332-8.

18. Chen X, Liu YN, Zhou QH, Leng L, Chang Y, Tang NJ*. Effects of low concentrations of di-(2-ethylhexyl) and mono-(2-ethylhexyl) phthalate on steroidogenesis pathways and apoptosis in the murine leydig tumor cell line MLTC-1. Biomed Environ Sci. 2013, 26(12):986-9.

19. Chen X, Ma SW, Ma XM, Xu YJ, Tang NJ*. Changes in fibrinopeptide A peptides in the sera of rats chronically exposed to low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Environ Toxicol Pharmacol. 2012, 33(2):191-6.

20. Chen X, Ma XM, Ma SW, Coenraads PJ, Zhang CM, Liu J, Zhao LJ, Sun M, Tang NJ*. Proteomic analysis of the rat ovary following chronic low-dose exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). J Toxicol Environ Health A. 2009, 72(11-12):717-26.

21. Ma J, Chen X (Co-first Authors), Liu Y, Xie Q, Sun Y, Chen J, Leng L, Yan H, Zhao B, Tang N*. Ancestral TCDD exposure promotes epigenetic transgenerational inheritance of imprinted gene Igf2: Methylation status and DNMTs.Toxicol Appl Pharmacol. 2015, 289(2):193-202.

22. Zhang LW, Chen X (Co-first Authors), Xue XD, Sun M, Han B, Li CP, Ma J, Yu H, Sun ZR, Zhao LJ, Zhao BX, Liu YM, Chen J, Wang PP, Bai ZP*, Tang NJ*. Long-term exposure to high particulate matter pollution and cardiovascular mortality: a 12-year cohort study in four cities in northern China. Environ Int. 2014, 62:41-7.

23. Dong GH, Zhang P, Sun B, Zhang L, Chen X, Ma N, Yu F, Guo H, Huang H, Lee YL, Tang N, Chen J*. Long-term exposure to ambient air pollution and respiratory disease mortality in Shenyang, China: a 12-year population-based retrospective cohort study. Respiration. 2012, 84(5):360-8.

24. Bao J, Zeng XW, Qin XD, Lee YL, Chen X, Jin YH, Tang NJ, Dong GH*. Phthalate Metabolites in Urine Samples from School Children in Taipei, Taiwan. Arch Environ Contam Toxicol. 2015, 69(2):202-7.

25. Zhang P, Dong G, Sun B, Zhang L, Chen X, Ma N, Yu F, Guo H, Huang H, Lee YL, Tang N, Chen J*. Long-term exposure to ambient air pollution and mortality due to cardiovascular disease and cerebrovascular disease in Shenyang, China. PLoS One. 2011;6(6):e20827.

26. Liu J, Zhang CM, Coenraads PJ, Ji ZY, Chen X, Dong L, Ma XM, Han W, Tang NJ*. Abnormal expression of MAPK, EGFR, CK17 and TGk in the skin lesions of chloracne patients exposed to dioxins. Toxicol Lett. 2011, 25;201(3):230-4.

27. Guo L, Peng C, Xu H, Wilson A, Li PH, Wang H, Liu H, Shen L, Chen X, Qi X, Tang NJ, Barrow TM, Byun HM. Age at menarche and prevention of hypertension through lifestyle in young Chinese adult women: result from project ELEFANT. BMC Womens Health. 2018 Nov 9;18(1):182.

28. Li C, Liu JC, Xiao X, Chen X, Yue S, Yu H, Tian FS, Tang NJ. Psychological distress and type 2 diabetes mellitus: a 4-year policemen cohort study in China. BMJ Open. 2017 Jan 27;7(1):e014235.

29. Yu H, Liu JC, Fan YJ, Li C, Zhang LX, Chen X, Yue S, Lu WL, Yang XL, Tang NJ. Association between occupational stressors and type 2 diabetes among Chinese police officers: a 4-year follow-up study in Tianjin, China. Int Arch Occup Environ Health. 2016 Feb;89(2):277-88.

30. Leng L, Chen X, Li CP, Luo XY, Tang NJ. 2,3,7,8-Tetrachlorodibezo-p-dioxin exposure and prostate cancer: a meta-analysis of cohort studies. Public Health. 2014 Mar;128(3):207-13.

31. Regazzoni LG, Grigoryan H, Ji Z, Chen X, Daniels SI, Huang D, Sanchez S, Tang N, Sillé FC, Iavarone AT, Williams ER, Zhang L, Rappaport SM. Using lysine adducts of human serum albumin to investigate the disposition of exogenous formaldehyde in human blood. Toxicol Lett. 2017 Feb 15;268:26-35.

社会兼职

中华预防医学会环境卫生分会委员

中国毒理学会工业毒理学专业委员会委员

中华预防医学会毒理分会委员

中国环境诱变剂学会生物标志物专业委员会委员

天津市预防医学会毒理分会委员

天津市预防医学会环境卫生分会委员

天津市预防医学会劳动卫生分会委员

ISEE Membership (International Society for Environmental Epidemiology)

《中国职业医学》第九届编辑委员会委员

参编教材

职业病三级预防理论与实践. 人民卫生出版社. 2022年6月30日. ISBN：9787117332163.

二噁英类污染物的人体暴露评估. 中国环境出版社. 2016年12月. ISBN: 9787511130266.

持久性有机污染物与健康. 湖北科学技术出版社. 2019年10月. ISBN: 97875570603404.

公共卫生与预防医学（双语版）. 中国科学院教材建设专家委员会规划教材. 医学英文原版改编双语教材. 2021年3月. ISBN: 9787030657701